abstract::Mycobacterium ulcerans is the causal agent of Buruli ulcer, a chronic infectious disease and the third most common mycobacterial disease worldwide. Without early treatment, M. ulcerans provokes massive skin ulcers, caused by the mycolactone toxin, its main virulence factor. However, spontaneous healing may occur in Bu...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1929749
更新日期:2021-12-01 00:00:00
abstract::COVID-19, a pandemic disease caused by a viral infection, is associated with a high mortality rate. Most of the signs and symptoms, e.g. cytokine storm, electrolytes imbalances, thromboembolism, etc., are related to mitochondrial dysfunction. Therefore, targeting mitochondrion will represent a more rational treatment ...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章,评审
doi:10.1080/14756366.2021.1937144
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVES:Erectile dysfunction (ED) is the persistent inability to attain and/or maintain erection sufficient for satisfactory sexual performance. Chronic kidney disease (CKD) is a problem with increasing incidence every day which disrupts quality of life significantly. We aimed to research whether ED is a warning sym...
journal_title:The aging male : the official journal of the International Society for the Study of the Aging Malepub_type: 杂志文章
doi:10.1080/13685538.2021.1936483
更新日期:2021-12-01 00:00:00
abstract::Colorectal cancer (CRC) is graded as one of the most common cancer. It accounts for the second leading cause of cancer deaths worldwide. The present study intends to investigate the role and importance of different biochemical variables in the development of colorectal cancer.In this cross-sectional study we recruited...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1933680
更新日期:2021-12-01 00:00:00
abstract::The thiazolidinone ring is found in compounds that have widespan biology activity and there is mechanism-based evidence that compounds bearing this moiety inhibit P. aeruginosa PhzS (PaPzhS), a key enzyme in the biosynthesis of the virulence factor named pyocyanin. Ten novel thiazolidinone derivatives were synthesised...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2021.1931165
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Huoxiangzhengqi oral liquid (HXZQ-OL), a traditional Chinese medicine formula, has antibacterial, anti-inflammation and gastrointestinal motility regulation effects. OBJECTIVE:The study investigates the anti-allergic activity and underlying mechanism of HXZQ-OL. MATERIALS AND METHODS:IgE/Ag-mediated RBL-2H3 c...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2021.1928242
更新日期:2021-12-01 00:00:00
abstract::Docetaxel has been proved to provide survival benefit for advanced prostate cancer (PCa) patients. Resistance to docetaxel further reduces the survival of these patients. Herein, we performed a comprehensive bioinformatic analysis to identify differentially expressed genes (DEGs) between docetaxel sensitive and resist...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1936831
更新日期:2021-12-01 00:00:00
abstract::Excessive activation of signal transducer and activator of transcription 3 (STAT3) is implicated in breast cancer (BC) chemoresistance, but its underlying mechanism is not fully understood. There are STAT3 binding sites in fat mass and obesity-associated protein (FTO) promoter region, thus STAT3 may regulate the trans...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1924544
更新日期:2021-12-01 00:00:00
abstract::The fungal pathogen Candida auris has emerged as a new threat to human health. We previously reported the first isolate of C. auris (BJCA001) in China, which belongs to the South Asian clade (I) and was susceptible to all antifungals tested. In this study, we report the isolation of a drug-resistant C. auris strain (B...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1928410
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Early reports indicate that AKI is common during COVID-19 infection. Different mortality rates of AKI due to SARS-CoV-2 have been reported, based on the degree of organic dysfunction and varying from public to private hospitals. However, there is a lack of data about AKI among critically ill patients with CO...
journal_title:Renal failurepub_type: 杂志文章,多中心研究
doi:10.1080/0886022X.2021.1933530
更新日期:2021-12-01 00:00:00
abstract::The microbiota is a dynamic ecosystem that plays a major role in the host health. Numerous studies have reported that alterations in the intestinal microbiota (dysbiosis) may contribute to the pathogenesis of various common diseases such as diabetes, neuropsychiatric diseases, and cancer. However, emerging findings al...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1925150
更新日期:2021-12-01 00:00:00
abstract::A simple mRNA vaccine was shown to protect mice against tuberculosis more than 15 years ago. Like COVID-19, tuberculosis is a respiratory infection killing over a million people per year. It too presents a global emergency. Can the stunning success of RNA vaccination against COVID-19 be replicated for TB? ...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1935328
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Prostate cancer (PCa) is poor response to the immunotherapy for its high heterogeneity of immune microenvironment. In this study, we aim to introduce a new immune subtype for PCa involving M2 tumour associated macrophages (M2-TAMs). METHODS:Three hundred and sixty-two PCa patients and matched normal prostat...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1924396
更新日期:2021-12-01 00:00:00
abstract::Inhibitors of COMT are clinically used for the treatment of Parkinson's disease. Here, we report the first natural pentacyclic triterpenoid-type COMT inhibitors and their structure-activity relationships and inhibition mechanism. The most potent compounds were found to be oleanic acid, betulinic acid and celastrol wit...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2021.1928112
更新日期:2021-12-01 00:00:00
abstract::Candida auris is an emerging pathogenic fungal species found worldwide. Since April 2016, C. auris colonization/infection cases have been found in a general hospital in Shenyang, China. The genome-based phylogenetic studies of these isolates remain undefined. In the current study, the microbiological characteristics a...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1934557
更新日期:2021-12-01 00:00:00
abstract::Aldo-Keto Reductase Family 1 Member B10 (AKR1B10) and Homeobox A5 (HOXA5) are both down-regulated in adrenocortical carcinoma (ACC), and HOXA5 is predicted to bind to the promoter of AKR1B10. We aimed to investigate whether HOXA5 could bind to AKR1B10 to regulate ACC cells proliferation and apoptosis. The expression o...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1924545
更新日期:2021-12-01 00:00:00
abstract:PURPOSE:To evaluate the effect of hormone replacement therapy (HRT) on lens opacity as measured by Scheimpflug densitometry, serum inflammatory cytokines, and antioxidant levels. METHODS:A total of 264 women who were at least five years beyond menopause were included. The control group of 128 patients (Group 1) did no...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1928275
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Cerebral ischaemia/reperfusion (I/R) injury has a high disability and fatality worldwide. Myrtenol has protective effects on myocardial I/R injury through antioxidant and anti-apoptotic effects. OBJECTIVE:This study investigated the effect of myrtenol on cerebral ischaemia/reperfusion (I/R) injury and the unde...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2021.1917626
更新日期:2021-12-01 00:00:00
abstract::Testicular cancer is the most common malignant tumor in young men, and its incidence has increased in recent years. The tumor microenvironment (TME) plays a crucial role in the development and progression of tumors; however, the TME of testicular germ cell tumor (TGCT) is poorly understood. In this study, we downloade...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1927560
更新日期:2021-12-01 00:00:00
abstract::Southern Westfjords of Iceland is a sparsely populated, remote area with rather high proportion of older residents. This study´s aim was to investigate activities and participation in this population, using a descriptive cross-sectional population-based design. The participants were 129 community-dwelling residents, 6...
journal_title:International journal of circumpolar healthpub_type: 杂志文章
doi:10.1080/22423982.2021.1903778
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Broadening the skill-mix in general practice is advocated to build resilience into the primary care workforce. However, there is little understanding of how extended-scope practitioners from different disciplines, such as paramedicine and nursing, embed into roles traditionally ascribed to general practition...
journal_title:The European journal of general practicepub_type: 杂志文章
doi:10.1080/13814788.2021.1909565
更新日期:2021-12-01 00:00:00
abstract::In Germany, two-week clinical clerkships in university-associated general practices have existed since 2002. Approximately 10,000 medical students participate in these decentral clerkships each year. Empirical information on quality management strategies in decentral learning environments is sparse. This nationwide st...
journal_title:Medical education onlinepub_type: 杂志文章
doi:10.1080/10872981.2021.1923114
更新日期:2021-12-01 00:00:00
abstract::Loop diuretics are among the most widely used drugs worldwide and are commonly employed in the management of complications associated with acute kidney injury (AKI), namely volume overload and electrolyte management. The use of loop diuretics in critically ill patients with AKI is paramount to preventing or treating p...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1906701
更新日期:2021-12-01 00:00:00
abstract::Ultrasound (US)-guided central venous catheter (CVC) insertion is a procedure that carries the risk of significant complications. Simulation provides a safe learning atmosphere, but most CVC simulators are not available outside of simulation centers. To explore longitudinal trends in US-guided CVC insertion competency...
journal_title:Medical education onlinepub_type: 杂志文章
doi:10.1080/10872981.2021.1924350
更新日期:2021-12-01 00:00:00
abstract::Unique features of elephant hematology are known challenges in analytical methodology like two types of monocytes typical for members of the Order Afrotheria and platelet counts of the comparatively small elephant platelet. To investigate WBC differential and platelet data generated by an impedance-based hematology an...
journal_title:The veterinary quarterlypub_type: 杂志文章
doi:10.1080/01652176.2020.1867329
更新日期:2021-12-01 00:00:00
abstract::Purpose: The overall aim of the present study was to explore the experiences of older adult exercisers participating in an individualized training program lasting 3 months preparing for completing a triathlon competition. Methods: Fourteen older Norwegian adults (median age (interquartile range, IQR) for males (N=10) ...
journal_title:International journal of qualitative studies on health and well-beingpub_type: 杂志文章
doi:10.1080/17482631.2021.1872824
更新日期:2021-12-01 00:00:00
abstract::In various malaria-endemic regions, the appearance of resistance has precluded the use of pyrimidine-based antifolate drugs. Here, a three-step fragment screening was used to identify new non-pyrimidine Plasmodium falciparum dihydrofolate reductase (PfDHFR) inhibitors. Starting from a 1163-fragment commercial library,...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2020.1854244
更新日期:2021-12-01 00:00:00
abstract::Medical history of the city of Rijeka is a rich treasure trove of events, celebrities and valuable innovations in the field of healthcare. The historical development of Rijeka was largely determined by her geopolitical position as a border town with a multicultural population, marked by strong conflicts of interest an...
journal_title:Acta medico-historica adriatica : AMHApub_type: 传,历史文章,杂志文章
doi:10.31952/amha.18.2.5
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Panax ginseng C.A. Meyer (Araliaceae) has cardioprotective effects. Ginsenosides are responsible for most of the pharmacological activities of ginseng. OBJECTIVE:This study investigates the effect of ginsenoside Rg2 on myocardial fibrosis in myocardial ischaemia rats. MATERIALS AND METHODS:Male Wistar rats we...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2020.1867197
更新日期:2021-12-01 00:00:00
abstract::Candida parapsilosis is an emergent opportunistic yeast among hospital settings that affects mainly neonates and immunocompromised patients. Its most remarkable virulence traits are the ability to adhere to prosthetic materials, as well as the formation of biofilm on abiotic surfaces. The Ndt80 transcription factor wa...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1878743
更新日期:2021-12-01 00:00:00
abstract::It is now clear that the intercellular transport on microtubules by dynein and kinesin-1 motors has an important role in the replication and spread of many viruses. Porcine epidemic diarrhea virus (PEDV) is an enveloped, single-stranded RNA virus of the Coronavirus family, which can infect swine of all ages and cause ...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1878748
更新日期:2021-12-01 00:00:00
abstract::The kynurenine pathway is the major tryptophan degradation routes generating bioactive compounds important in physiology and diseases. Depending on cell type it is initiated enzymatically by tryptophan-2,3-dioxygenase (TDO) or indoleamine-2,3-dioxygenase 1 and 2 (IDO1 and IDO2) to yield N-formylkynurenine as the precu...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2021.1882451
更新日期:2021-12-01 00:00:00
abstract::Salt-sensitive (SS) hypertension is accompanied with severe cardiorenal complications. In this condition, elevated blood pressure (BP) resulting from salt retention is associated with counterintuitively lower levels of atrial natriuretic peptide (ANP). In plasma, ANP is degraded by the neprilysin; therefore, pharmacol...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1879856
更新日期:2021-12-01 00:00:00
abstract::The aim of this study was to prepare and characterise inclusion complexes of a low water-soluble drug, mefenamic acid (MA), with β-cyclodextrin (β-CD). First, the phase solubility diagram of MA in β-CD was drawn from 0 to 21 × 10-3 M of β-CD concentration. A job's plot experiment was used to determine the stoichiometr...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2020.1869225
更新日期:2021-12-01 00:00:00
abstract::Online classes have been provided for health-care pre-licensure learners during the novel coronavirus disease 2019 pandemic. The purpose of this study was to evaluate the utility of online group work in interprofessional education. A total of 209 students were assigned to 50 groups (18 medical student groups, 13 nursi...
journal_title:Medical education onlinepub_type: 杂志文章
doi:10.1080/10872981.2021.1886649
更新日期:2021-12-01 00:00:00
abstract::The activity-dependent trafficking of AMPA receptors (AMPAR) mediates synaptic strength and plasticity, while the perturbed trafficking of the receptors of different subunit compositions has been linked to memory impairment and to causing neuropathology. In the spinal cord, nociceptive-induced changes in AMPAR traffic...
journal_title:Channels (Austin, Tex.)pub_type: 杂志文章
doi:10.1080/19336950.2021.1885836
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:The leech and centipede granules have good curative effects on many diabetic vascular diseases, including diabetes-induced erectile dysfunction (DIED). OBJECTIVE:To explore the effect of leech and centipede on erectile function in rats with diabetes-induced erectile dysfunction and its possible mechanism. MAT...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2021.1878237
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVE:This study aimed to investigate whether the antihypertensive effect of irbesartan (IRB) in spontaneously hypertensive rats (SHR) was achieved through improvement of insulin resistance and adjustment of the LPN-APN imbalance. METHODS:SHR rats were divided into SHAM, SHR-A and SHR-I group(8 per group). Homolog...
journal_title:Adipocytepub_type: 杂志文章
doi:10.1080/21623945.2021.1886409
更新日期:2021-12-01 00:00:00
abstract::This study investigated anti-polyphenol oxidase activity and mechanism of purified total flavonoids (PTF) from young loquat fruits. PTF remarkably inhibited the activity of polyphenol oxidase (PPO) with an IC50 value of 21.03 ± 2.37 μg/mL. Based on enzyme kinetics, PTF was found to be a potent, mixed-type, and reversi...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1886387
更新日期:2021-12-01 00:00:00
abstract::Adipose tissue blood flow (ATBF) is an important determinant of adipose tissue (AT) function. 133Xenon wash-out technique is considered the gold-standard for human ATBF measurements. However, decreasing 133Xenon clinical use and costly production and preservation, make alternative (non-invasive) methods necessary. Her...
journal_title:Adipocytepub_type: 杂志文章
doi:10.1080/21623945.2021.1888471
更新日期:2021-12-01 00:00:00